Toxic Multinodular Goiter with Low Radioactive Iodine Uptake

Recombinant human TSH and radioactive iodine therapy in the management of benign multinodular goiter.

Multinodular goiter (MNG) is a very common thyroid disorder determined by diverse goitrogenic factors, the most important one being iodine deficiency. The clinical presentation of a patient with MNG varies from a completely asymptomatic goiter to a life-threatening disease due to upper airway compression. Patients can develop underlying subclinical or overt hyperthyroidism due to autonomously h...

Thyroid cancer in toxic and non-toxic multinodular goiter.

BACKGROUND Many authors have claimed that hyperthyroidism protects against thyroid cancer and believed that the incidence of malignancy is lower in patients with toxic multinodular goiter (TMG) than in those with non-toxic multinodular goiter. But in recent studies, it was reported that the incidence of malignancy with TMG is not as low as previously thought. AIM To compare the thyroid cancer...

UpToDate®: 'Treatment of toxic adenoma and toxic multinodular goiter'

There are two clinical situations in which establishing the diagnosis of a toxic adenoma or toxic multinodular goiter is more difficult. First, the autonomously functioning tissue may be sufficiently diffuse that it is difficult to differentiate a toxic multinodular goiter from Graves' disease by thyroid scintigraphy alone. When it is important to distinguish these disorders, a high serum conce...

Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre.

Iodine-123 SPECT of the thyroid in multinodular goiter.

Iodine-123 single photon emission computed tomography (SPECT) imaging of the thyroid was performed in two patients with multinodular goiter and swallowing difficulty to provide the functional and anatomic orientation of the goiter in relation to the airway. Transaxial slices showed the retrolaryngeal extension of the enlarged thyroid and the tracheal compression by the goiter in both patients. ...